COLLOQUIUM
3:00 p.m., Friday (October 17, 2008)
MATX 1100
Yue-Xian Li
Department of Mathematics
UBC
Modeling Hormonal Rhythms in a Network of Endocrine Neurons
Abstract: The regulation of reproductive function and fertility is
ultimately controlled by a pulsatile signal of gonadotropin-releasing
hormone (GnRH). GnRH is synthesized and secreted by a few hundred GnRH
neurons in the hypothalamus that work in synchrony to produce this
pulsatile rhythm. The mysteries surrounding the rhythmogenesis in GnRH
neurons remain defiant to any conventional knowledge of
rhythm-generation in neuronal networks. Efforts to crack this puzzle
have been pushing the frontier of classical neuroscience that
traditionally only focused on ionotropic channel events with time
scales of milliseconds to the inclusion of metabotropic receptors,
second messengers, vesicle transportation and docking,
autocrine/parcrine regulations, as well as genetic events. Mathematical
modeling of this rhythm gives rise to challenging nonlinear mathematical
problems one has never encountered before. This talk will present a
brief summary of important progress in recent years including our own
contributions to solving this puzzle.
Refreshments will be served at 2:45 p.m. (Math Lounge, MATX 1115).
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